Hola from Minnesota where it has been beautiful outside, and my back is at about 90%. I was able to hop on the Concept2 rower 3 days in a row!

Wahooo!

In my email yesterday, I walked out on the wobbly branch of limited research in regard to the use of senolytics – compounds that may clean up dysfunctional cells.

As I stated in the newsletter yesterday, all the basics (like nutrition, sleep and exercise) are the first step, as they appear to have senolytic qualities by themselves.

For example, here is a review that discusses the potential ability of exercise to be a senolytic (1).

No pill or potion will ever replace all of the benefits of exercise!

And to address another important point, the data currently on the use of senolytics is still very much in its infancy.

We have lots of mechanistic data in small rodents and cells, but not as much in humans.

One of the main ingredients in Senolytic from Nuerohacker is a compound called fisetin.

Fiestin is a yellow pigment found in plants. It's found in strawberries, apples, persimmon, grapes, onions, and cucumbers for example.

The rodent and cell data on fiestin is quite robust; but as you know- since you are a smart cookie reading this newsletter – that does not mean it will translate to humans.

Right now there are only 4 randomized controlled trials (aka RCTs- the studies that nerds get all excited about) in very different disease (2-5). The data from them is quite mixed.

There are 5 human clinical trials underway using fiestin – generally in older adults and even as a potential therapy for COVID (6-10). Hopefully in the near future we will have more data from them.

In the meantime, we know that the safety data is good and if you want to hedge your bets in the longevity space – after you are crushing the basics- adding a supplement like Senolytic is one method.

>> Neurohacker Senolytic <<

Use the coupon code DRMIKE to save an extra 15%.

Plus, using DRMIKE provides an extra 15% off any order, including subscriptions!!

As stated before, this is an affiliate link so I do make a bit of coin if you purchase.

Honestly, the amount I make is small, but I know some of you are looking for the bleeding edge to test out; so my job is to help point you in a better direction and ways to stay clear from the completely bat sheeeet crazy celery juice cleanse or cucumber enemas.

Any questions, just hit reply.

Much love,

Dr Mike

>> Neurohacker Senolytic <<

Use the coupon code DRMIKE to save an extra 15%!

References

1) Chen XK, Yi ZN, Wong GT, Hasan KMM, Kwan JS, Ma AC, Chang RC. Is exercise a senolytic medicine? A systematic review. Aging Cell. 2021 Jan;20(1):e13294. doi: 10.1111/acel.13294. Epub 2020 Dec 30. PMID: 33378138; PMCID: PMC7811843.

2) Wang L, Cao D, Wu H, Jia H, Yang C, Zhang L. Fisetin Prolongs Therapy Window of Brain Ischemic Stroke Using Tissue Plasminogen Activator: A Double-Blind Randomized Placebo-Controlled Clinical Trial. Clin Appl Thromb Hemost. 2019 Jan-Dec;25:1076029619871359. doi: 10.1177/1076029619871359. PMID: 31434498; PMCID: PMC6829632.

3) Hodgin KS, Donovan EK, Kekes-Szabo S, Lin JC, Feick J, Massey RL, Ness TJ, Younger JW. A Placebo-Controlled, Pseudo-Randomized, Crossover Trial of Botanical Agents for Gulf War Illness: Resveratrol (Polygonum cuspidatum), Luteolin, and Fisetin (Rhus succedanea). Int J Environ Res Public Health. 2021 Mar 3;18(5):2483. doi: 10.3390/ijerph18052483. PMID: 33802381; PMCID: PMC7967624.

4) Farsad-Naeimi A , Alizadeh M , Esfahani A , Darvish Aminabad E . Effect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients. Food Funct. 2018 Apr 25;9(4):2025-2031. doi: 10.1039/c7fo01898c. PMID: 29541713.

5) Kwak JH, Lee HJ, Jeong ST, Lee JY, Lee M, Paik JK. Effect of fermented Rhus verniciflua stokes extract on liver function parameters in healthy Korean adults: a double-blind randomized controlled trial. Trials. 2021 Nov 22;22(1):830. doi: 10.1186/s13063-021-05656-0. PMID: 34809689; PMCID: PMC8607399.

6) History of Changes for Study: NCT04771611​

7) History of Changes for Study: NCT03325322​

8) History of Changes for Study: NCT04476953​

9) History of Changes for Study: NCT03430037​

10) Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Adults - Full Text View - ClinicalTrials.gov